Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates
نویسندگان
چکیده
منابع مشابه
Leveraging distant relatedness to quantify human
20 The rate at which human genomes mutate is a central biological parameter that 21 has many implications for our ability to understand demographic and evolutionary 22 phenomena. We present a method for inferring mutation and gene conversion rates 23 using the number of sequence differences observed in identical-by-descent (IBD) 24 segments together with a reconstructed model of recent populati...
متن کاملComparison of Vero and MDCK cell lines transfected with human siat7e gene for conversion to suspension culture
Introduction: Inactivated influenza vaccines are traditionally produced in chicken embryonated eggs but its limitations in producing the required doses in pandemic outbreaks quickly enough has made searching for alternative modes of production necessary. The use of cell culture-based vaccine production is one way of overcoming the limitations of the egg-based method and securing a more rapid re...
متن کاملJoint estimation of gene conversion rates and mean conversion tract lengths from population SNP data
MOTIVATION Two known types of meiotic recombination are crossovers and gene conversions. Although they leave behind different footprints in the genome, it is a challenging task to tease apart their relative contributions to the observed genetic variation. In particular, for a given population SNP dataset, the joint estimation of the crossover rate, the gene conversion rate and the mean conversi...
متن کاملMutation Rates and Gene Location: Some Like It Hot
PLoS Biology | http://biology.plosjournals.org Of the 300 or so viruses that cause disease in humans, HIV may have the greatest adaptive advantage. Like most persistent viruses—including the herpesviruses Epstein–Barr and cytomegalovirus (CMV)—HIV employs various strategies to counteract its host’s response to infection. But HIV possesses a unique ability to sustain a progressive attack on the ...
متن کاملUsing Somatic Mutation Data to Test Tumors for Clonal Relatedness.
A major challenge for cancer pathologists is to determine whether a new tumor in a patient with cancer is a metastasis or an independent occurrence of the disease. In recent years numerous studies have evaluated pairs of tumor specimens to examine the similarity of the somatic characteristics of the tumors and to test for clonal relatedness. As the landscape of mutation testing has evolved a nu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2015
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2015.10.006